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Familial Multiple Lipomatosis is a poorly understood condition because it is so rare. It is characterized by multiple painless lipomas that are distributed throughout the trunk and extremities. It is diagnosed when it occurs in more than one family member, sometimes over several generations.

Global lipomas that spare the head and shoulders is a strong cardinal symptom of FML. The lipomas occur in subcutaneous fat and they can occur in connective tissues. They may be attached to skin, muscle, or any structures. This does not cause pain, but can result in irritation. Progression of lipomas can lead to disfigurement, impaired mobility, and disability.

Currently, treatment protocols for familial multiple lipomatosis include surgical excision, endoscopic removal or liposuctions of lipomas and surrounding tissue. Pain management should be offered to patients with advanced growth that have led to mobility issues. There are online support groups of patients and family members.

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